| Main Title |
Health assessment document for acrylonitrile / |
| Author |
Neal, Michael W. ;
Basu, Dipak K. ;
Sugatt, Richard H. ;
Hsu, Robert S. ;
Santodonato, Joseph
|
| Other Authors |
|
| CORP Author |
United States. Environmental Protection Agency. Office of Research and Development.; Syracuse Univ. Research Corp., NY.; Environmental Protection Agency, Research Triangle Park, NC. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, |
| Year Published |
1982 |
| Report Number |
EPA-600-8-82-007; SRC-TR-81-596; EPA-68-02-3277; PB83129593 |
| Stock Number |
PB83-129593 |
| OCLC Number |
10190184 |
| Subjects |
Environmental health ;
Acrylonitrile--Toxicology ;
Carcinogens
|
| Additional Subjects |
Environmental health ;
Acrylonitrile--Toxicology ;
Carcinogens ;
Acrylonitriles ;
Physical properties ;
Chemical properties ;
Sampling ;
Sources ;
Residues ;
Transport ;
Distribution ;
Exposure ;
Concentration(Composition) ;
Humans ;
Laboratory animals ;
Air quality ;
Analytical methods ;
Biological effects ;
Toxic substances
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EHAM |
EPA-600-8-82-007 |
|
Region 1 Library/Boston,MA |
05/25/2016 |
| EKBD |
EPA-600/8-82-007 |
|
Research Triangle Park Library/RTP, NC |
03/19/2004 |
| ESAD |
EPA 600-8-82-007 |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
| NTIS |
PB83-129593 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1 volume (various pagings) ; 28 cm |
| Abstract |
Acrylonitrile is readily absorbed in animals following ingestion or inhalation, while dermal absorption is poor (1%) compared to that of the lungs. Acrylonitrile is metabolized to cyanide, which is transformed to thiocyanic acid and by cyanoethylation of sulfhydryl groups to S-(2 cyanoethyl) cysteine, followed by elimination of these metabolites in the urine. Symptoms of intoxication in humans include eye and nose irritation, weakness, labored breathing, dizziness, impaired judgement, cyanosis, nausea and convulsions. Similar symptoms have been observed in animals, including death. In experimental animals, there is considerable species variation in susceptibility to acrylonitrile intoxication; the guinea pig is the most resistant and the dog the most sensitive. Many of the pathological changes observed in rats under chronic exposure conditions are believed to be treatment related. |
| Notes |
"Draft. Do not cite or quote." "EPA-600/8-82-007." "November 1982." Includes bibliographical references. |
