| Main Title |
Effect of pesticide interactions upon the reproductive system / |
| Author |
Thomas, John ;
Thomas, John A.
|
| Other Authors |
|
| CORP Author |
West Virginia Univ. Medical Center, Morgantown. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, N.C. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory, |
| Year Published |
1978 |
| Report Number |
PB285203; EPA-600/1-78-044; EPA-R-803578 |
| Stock Number |
PB-285 203 |
| OCLC Number |
52490289 |
| Subjects |
Pesticides--Toxicology ;
Reproductive toxicology
|
| Additional Subjects |
Pesticides ;
Dieldrin ;
Toxicology ;
Tables(Data) ;
Insecticides ;
In vitro analysis ;
Rats ;
Mice ;
Laboratory animals ;
Experimental data ;
Testosterone ;
Sex hormones ;
Metabolism ;
Prostate gland ;
Liver ;
Ingestion(Biology) ;
Physiological effects ;
Sensitivity ;
Reproductive system ;
Interactions ;
Biological effects ;
Parathion ;
Phosphorothioic acid/0-0-(dimethyl-ester)-0-(nitrophenyl-ester) ;
Toxic substances
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-78-044 |
c.1 |
Headquarters Library/Washington,DC |
04/28/2014 |
| ELBD ARCHIVE |
EPA 600-1-78-044 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD RPS |
EPA 600-1-78-044 |
repository copy |
AWBERC Library/Cincinnati,OH |
05/08/2019 |
| NTIS |
PB-285 203 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
ix, 39 pages : illustrations ; 28 cm. |
| Abstract |
The metabolism of 1,2-3H-testosterone in vitro was studied in prostate glands and livers of rats and mice treated with different pesticides including dieldrin and parathion. The metabolism of 1,2-3H-testosterone (T-3H) in vitro by mouse anterior prostate glands or hepatic microsomes has been studied after the oral administration of dieldrin (2.5 mg/kg daily x 5 or 10) and/or parathion (1.3,2.6, or 5.2 mg/kg daily x 5 or 10). T-3H metabolism in the prostate was unaffected by the various treatment regimens. Dieldrin (10 days) caused some reduction in the microsomal production of androstenedione-3H or dihydrotestosterone-3H. Only treatment regimes with dieldrin stimulated hepatic testosterone hydroxylases; parathion alone had no effect. This study revealed that dieldrin and parathion can interact and produce biological effects different from those caused by either pesticide alone. |
| Notes |
Project Officer: Ronald L. Baron. Department of Pharmacology, West Virginia University Medical Center "June 1978." "EPA-600/1-78-044." PB 285 203--NTIS. "Publication resulting from this EPA Grant" (p.36-37). Includes bibliographical references (pages 31-35). |
