Record Display for the EPA National Library Catalog


Main Title Assessment of risks to human reproduction and to development of the human conceptus from exposure to environmental substances : proceedings of U.S. Environmental Protection Agency-sponsored conferences, October 1-3, 1980, Atlanta, Georgia, and December 7-10, 1980, St. Louis, Missouri.
Author Galbraith, W. M. ; Voytek, P. ; Ryon, M. G.
CORP Author Oak Ridge National Laboratory. Chemical Effects Information Center.; United States. Environmental Protection Agency. Office of Health and Environmental Assessment.
Publisher Oak Ridge National Laboratory ; U.S. Environmental Protection Agency, Office of Health and Environmental Assessment ; Available from National Technical Information Service,
Year Published 1982
Report Number EPA 600/9-82-001; ORNL/EIS-197; W-7405-ENG-26; CONF--8010259--Summ.; CONF--801286--Summ.
Stock Number DE82007897
OCLC Number 09179056
Subjects Reproductive toxicology--Congresses ; Health risk assessment--Congresses ; Chemicals--Physiological effect--Congresses
Additional Subjects Human reproduction--Congresses ; Chemicals--Physiological effects--Congresses ; Poisons--Physiological effects--Congresses ; Toxic materials ; Reproductive disorders ; Males ; Females ; Reproduction ; Teratogens ; Risk assessment ; Toxicity ; Pharmacology ; Epidemiology ; Fetuses ; Behavior ; Biological effects ; Man ; Ontogenesis ; ERDA/560306
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJED  EPA 600/9-82-001 OCSPP Chemical Library/Washington,DC 01/01/1988
ELBD ARCHIVE EPA 600-9-82-001 AWBERC Library/Cincinnati,OH 02/10/2022
ERAD  EPA 600/9-82-001 Region 9 Library/San Francisco,CA 03/04/2013
ESAD  EPA 600-9-82-001 Region 10 Library/Seattle,WA 03/23/2010
NTIS  DE82007897 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xi, 158 p. : ill. ; 23 cm.
The Offices of Health Research and of Health and Environmental Assessment within the Office of Research and Development sponsored a conference to produce a technical document on the current status of risk assessment methodologies for teratogenic and other reproductive effects. The conference brought together scientists knowledgeable in reproductive biology and teratology to discuss techniques and concepts pertinent to developing risk assessment methodologies. The document is divided into three main subject areas: assessment of toxicity to female reproduction, assessment of toxicity to male reproduction, and assessment of toxicity to the conceptus. There are three supplemental parts: pharmacokinetics and epidemiologic considerations, which are common to all toxicological assessments, and a special section on the behavioral aspects of sexual development. The specific areas addressed are the potential adverse effects on the female and male reproductive systems as well as adverse effects on the developing conceptus. A broad range of problems and effects are discussed, including infertility, early resorption of the conceptus, and possible behavioral disorders producted by subtle changes in the biochemical environment of the fetus. Suggestions are given for improvement in standard toxicological protocols for evaluation of reproductive risks, identifies new concepts and procedures that can be immediately applicable, and designates those that need further expansion and development through research. Included is a discussion on the predictive ability of the tests in estimating risk. (ERA citation 07:051825)
"Chemical Effects Information Center, Information Center Complex, Information Division, Oak Ridge National Laboratory." "Work sponsored by the U.S. Environmental Protection Agency, Washington, D.C., under interagency agreements no. 80-D-X1011 and no. 81-D-X0453." "Published: February 1982." Includes bibliographical references and index. "Contract no. W-7405-eng-26." "ORNL/EIS-197." "EPA-600/9-82-001." Item 429-T-4 (microfiche)