Main Title |
Acute and Long-Term Effects of a Single Dose of the Fungicide Carbendazim (Methyl 2-Benzimidazole Carbamate) on the Male Reproductive System in the Rat. |
Author |
Nakai, M. ;
Hess, R. A. ;
Moore, B. J. ;
Guttroff, R. F. ;
Strader., L. F. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Illinois Univ. at Urbana-Champaign. Dept. of Veterinary Biosciences. ;Miyazaki Univ. (Japan). Dept. of Veterinary Anatomy.;National Institutes of Health, Bethesda, MD. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA/600/J-94/210; NIH-ES-05214; |
Stock Number |
PB94-163896 |
Additional Subjects |
Reproductive system ;
Toxicity ;
Males ;
Fungicides ;
Rats ;
Dose-response relationships ;
Pathology ;
Testis ;
Seminiferous tubules ;
Spermotozoa ;
Organ weight ;
Reprint ;
Carbendazim
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB94-163896 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
The effects of carbendazim (methyl 2-benzimidazole carbamate) on the testis, efferent ductules, and sperm were determined in the adult rate after a single oral dose. Two experimental trials were performed: a time response between 2 hours and 32 days after exposure using 0 and 400 mg/kg, and a dose response at 2 and 70 days after exposure using 0 to 800 mg/kg doses. A dose-dependent increase in testicular weight 2 days after treatment was accompanied by increases in seminiferous tubular diameter and excessive loss of immature germ cells in a stage-dependent manner. There was also a dose-dependent increased incidence of occlusions in the efferent ductules. The occluded ductules were characterized by severe inflammation and exhibited disorganization of the epithelium. At 70 days, there were dose-dependent decreases in mean testis weight and mean seminiferous tubular diameter; however, only minimal long-term effects were seen at 50 mg/kg. Results show that carbendazim produces more severe short- and long-term effects on the male reproductive system than the fungicide benomyl. |