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Main Title Statistical methods for estimating risk for exposure above the reference dose /
Author Knauf, Linda A. ; Hertzberg, R. C.
Other Authors
Author Title of a Work
Herzberg, Richard C.
CORP Author Computer Sciences Corp., Cincinnati, OH.;Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Environmental Criteria Assessment,
Year Published 1990
Report Number EPA/600/8-90/065; EPA-68-01-7176
Stock Number PB90-261504
Subjects Environmental toxicology ; Dose-response relationship (Biochemistry) ; Pollutants--Toxicology
Additional Subjects Toxicity ; Statistical analysis ; Regression analysis ; Mathematical models ; Exposure ; Dieldrin ; Nephritis ; Risk assessment ; Environmental pollution ; Dose-response relationships ; Computer applications ; Hexachlorobenzene
Library Call Number Additional Info Location Last
NTIS  PB90-261504 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 104 pages ; 28 cm
A statistical method has been developed that provides a risk estimate for noncarcinogenic effects at a given dose. The method uses a categorical regression procedure to model severity of effect as it relates to experimental dose. Toxicity data are analyzed from multiple animal experiments that span different species, target organs, toxic effects, and exposure conditions. The data are screened for homogeneity with respect to experiment duration and route of exposure. The resulting dose-response curve provides an estimate of the risk of adverse effects that may be useful in estimating risk for exposures above the reference dose (RfD).
Caption title. "EPA/600/8-90/065." "August 1990." Includes bibliographical references. Microfiche.