| Main Title |
Reference dose (RfD) : description and use in health risk assessments / |
| Author |
Barnes, D. G. ;
Dourson, M.
|
| Other Authors |
|
| CORP Author |
Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Environmental Criteria and Assessment Office, |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/310 |
| Stock Number |
PB89-202436 |
| Subjects |
Health risk assessment
|
| Additional Subjects |
Exposure ;
Toxicology ;
Reprints ;
Risk assessment ;
Reference dose ;
Health risks
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-202436 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
18 unnumbered pages ; 28 cm |
| Abstract |
For many years the concept of the 'acceptable daily intake' has served the toxicological and regulatory fields quite well. However, as approaches to assessing the health significance of exposures to noncarcinogenic substances receive greater scrutiny, some difficulties with this traditional approach have become more apparent. Consequently, the concept of the 'reference dose' is introduced in order to avoid use of prejudicial terms (e.g., 'safety' and 'acceptable'), to promote greater consistency in the assessment of noncarcinogenic chemicals, and to maintain the functional separation between risk assessment and risk management. |
| Notes |
"Paper published in Regulatory Toxicology and Pharmacology, 8:471-486 (1988)." "EPA/600/J-88/310." "PB89-202436." Document is used as a background document for records in the Integrated Risk Information System data base (IRIS). Microfiche. |
