Record Display for the EPA National Library Catalog

RECORD NUMBER: 27 OF 45

OLS Field Name OLS Field Data
Main Title Immune Response and Prevalence of Antibody to Norwalk Enteritis Virus as Determined by Radioimmunoassay.
Author Blacklow, Neil R. ; Cukor, George ; Bedigian, Mary Kay ; Echeverria, Peter ; Greenberg, Harry B. ;
CORP Author Massachusetts Univ. Medical School, Worcester.;Health Effects Research Lab., Cincinnati, OH.
Year Published 1981
Report Number EPA-R-805169 ;EPA-R-806591; EPA/600/J-79-128;
Stock Number PB81-232209
Additional Subjects Enteroviruses ; Viruses ; Antibodies ; Reprints ; Immune responses ; Radioimmunoassay
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB81-232209 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 9p
Abstract
A solid-phase microtiter radioimmunoassay was established for the detection of Norwalk virus and its antibody, with clinical materials from human volunteers previously studied in Massachusetts as reagents. A study of 308 Massachusetts residents showed that serum antibody to Norwalk agent was rarely present during childhood but was detectable in approximately 50% of adults. All volunteers inoculated with Norwalk virus who developed illness seroconverted (10/10), whereas only one-third (5/15) of nonill volunteers seroconverted (P=0.0009). The 10 nonill, nonseroconverting subjects had undetectable to low preexisting antibody levels. Paradoxically, 10/13 subjects with preexisting antibody became ill, whereas 17/25 lacking antibody did not (P=0.009). All 3 subjects with preexisting anti-Norwalk radioimmunoassay blocking activity in duodenal intraluminal fluids became ill, whereas only 5/11 lacking such activity developed illness (P=0.15). These data further support the unique concept that some individuals are susceptible to repeated infections with this agent, whereas others are incapable of developing infection.