Record Display for the EPA National Library Catalog


Main Title Automotive Exhaust and Mouse Activity: Relationships between Pollutant Concentrations and Decreases in Wheel Running.
Author Gage, Michael I. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1979
Report Number EPA/600/J-79/043;
Stock Number PB80-124126
Additional Subjects Carbon monoxide ; Exhaust gases ; Toxicity ; Radiation effects ; Mice ; Exposure ; Laboratory animals ; Respiration ; Males ; Females ; Relationships ; Activity ; Concentration(Composition) ; Reprints ; Automobile exhaust ; Air pollution effects(Animals) ; Toxic substances ; Environmental health
Library Call Number Additional Info Location Last
NTIS  PB80-124126 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Groups of male and female mice inhaled either clean air, 100 ppm carbon monoxide, or light-irradiated and nonirridiated automotive exhaust containing nominally 25, 50, 75, or 100 ppm carbon monoxide in three tests with exposure lasting from 4 to 7 days. Exhaust from a factory or lean-tuned engine in the first and third tests reversibly suppressed activity wheel running during exposure in mice of both sexes by as much as 78.3 and 83.1 percent respectively. Light-irradiated exhaust suppressed running more than nonirradiated exhaust. For the second test, when the engine was tuned to be low in pollutants other than carbon monoxide, exhaust did not suppress running. Exposure to carbon monoxide alone only slightly decreased running in male mice, but increased running in female mice.