| Main Title |
QSAR Modelling of the ERL-D Fathead Minnow Acute Toxicity Database. |
| Author |
Nendza, M. ;
Russom, C. L. ;
|
| CORP Author |
Environmental Research Lab.-Duluth, MN. ;Fraunhofer-Inst. fuer Umweltchemie und Oekotoxikologie, Schmallenberg (Germany, F.R.). |
| Publisher |
c1991 |
| Year Published |
1991 |
| Report Number |
EPA/600/J-91/068; |
| Stock Number |
PB91-196485 |
| Additional Subjects |
Water pollution effects(Animals) ;
Toxicity ;
Minnows ;
Organic chemicals ;
Data bases ;
Regression analysis ;
Tables(Data) ;
Reprints ;
Foreign technology ;
Quantitative structure-activity relationships model ;
Listings
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-196485 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
26p |
| Abstract |
Regression analysis has been applied to examine the structure-activity relationships regarding the acute fish toxicity (96 h LC50 fathead minnow) of organic chemicals. The log P dependent baseline toxicity model has been confirmed for a data set composed of 618 compounds from 24 chemical classes associated with a putative common mode of action. Covariance analysis of the discrete by class regression functions resulted in the combination of chemicals to subsets associated with their mode of action. Separate models were derived for nonpolar (Class I) and polar (Class II and III) compounds. Chemicals which are more toxic than estimated from the baseline model are identified. (Copyright (c) 1991 Taylor and Francis, Ltd.) |
