This document discusses a plan to develop and carry out a quality assurance program for the Ames/Salmonella test. The Ames test is in one of the 13 categories of tests mentioned in the Federal Insecticide, Fungicide, and Rodenticide Act legislation and is chosen as a model for presenting a QA program for all test categories. There are three main sections contained herein. An introductory section describes the laws requiring this testing and the objectives of this quality assurance plan. The second section defines quality assurance terms, describes applicable quality assurance methods, and discusses the mailable audit materials approach that was chosen for these purposes. The third section details the mailable audit materials program and discusses selection of chemicals, preparation of samples, shipment of audit samples, pilot-scale audits, scheduling, other audit programs as models, data gathering procedures, data analysis, reporting of results, and costs.