A broad-range research program was initiated to study the mutagenic and carcinogenic effects of diesel engine emissions and other related complex mixture samples. These studies featured a combined approach of analytical chemistry, genetic toxicity bioassay, and tumor bioassay to fully characterize both the complex mixtures themselves as well as individual components which might be responsible for biological activities. The paper briefly summarizes the approaches taken and the results obtained and cites previously published data. Also presented are some current research efforts aimed at furthering knowledge of these relationships.

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