Record Display for the EPA National Library Catalog


Main Title Pulmonary Function in Juvenile and Young Adult Rats Exposed to Low-Level NO2 with Diurnal Spikes.
Author Stevens, M. A. ; Menache, M. G. ; Crapo, J. D. ; Miller, F. J. ; Graham, J. A. ;
CORP Author Northrop Services, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1988
Report Number EPA-68-02-4032; EPA/600/J-88/020;
Stock Number PB88-219720
Additional Subjects Respiratory system ; Exposure ; Rats ; Nitrogen dioxide ; Lung ; Concentration(Composition) ; Ventilation ; Reprints ; Pulmonary function ; Lung compliance ; Health effects
Library Call Number Additional Info Location Last
NTIS  PB88-219720 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Pulmonary function was examined in juvenile and young adult Fischer-344 rats continuously exposed to NO2 (0.5, 1.0 or 2.0 ppm) for up to 6 weeks with twice daily 1 hr spikes equal to 3X the baseline concentration. The spike to baseline ratio was chosen to simulate morning and evening urban rush hour conditions. Juvenile rats were examined after 3 and 6 weeks of NO2 exposures, while young adult rats were examined after 1, 3, and 6 week intervals. Lung volumes, compliance, and efficiency of ventilation were evaluated. Lung volumes increased in the juvenile rats after 3 and 6 week exposures to 1.0 and 2.0 ppm, but were unchanged in young adult rats. Lung compliance increased in juvenile rats exposed to 1.0 or 2.0 ppm for 3 weeks, however, was unchanged in juvenile rats exposed for 6 weeks, as well as in the young adult rats exposed for 1 and 3 weeks. Compliance decreased in young adult rats exposed to 2.0 ppm for 6 weeks, and was correlated to an overall thickening of alveolar interstitium and spetal tissues.