Record Display for the EPA National Library Catalog


Main Title Definition of Airway Composition Within Gamma Camera Images.
Author Martonen, T. B. ; Yang, Y. ; Dolovich, M. ; Eng, P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;McMaster Univ., Hamilton (Ontario).
Publisher c1994
Year Published 1994
Report Number EPA/600/J-94/408;
Stock Number PB95-125381
Additional Subjects Trachea ; Bronchi ; Phamacokinetics ; Gamma cameras ; Anatomy ; Lung ; Inhalation administration ; Radionuclides ; Pulmonary alveoli ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB95-125381 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
The authors present an analytical model to assist the clinician in the systematic analysis and interpretation of gamma camera images to aid in assessing the efficacies of inhaled pharmacologic drugs in the prophylaxis and treatment of airway diseases. Using the Cray Y-MP supercomputer, a range of human lung morphologies has been mapped to function as templates that can be superimposed on scans. The model is intended to complement laboratory regimens by providing a previously unavailable method to define the C, I, and P zones of the human lung generation by generation. A quantitative value now can be assigned to the degree of overlappng that exists in the images. For example, for a typical lung morphology consisting of 16,777,215 airways (total), the C zone itself may contain 1,608,246 airways, of which 1,595,940, or 99.2%, are alveolated airways. By identifying composition, the authors' intent is to integrate the model into future aerosol therapy protocols and thereby assist procedures that target delivery of airborne pharmaceuticals.