Record Display for the EPA National Library Catalog


Main Title Pulmonary Effects Due to Subchronic Exposure to Oil Fog.
Author Selgrade, M. K. ; Hatch, G. E. ; Grose, E. C. ; Stead, A. G. ; Miller., F. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Inhalation Toxicology Div. ;Experimental Pathology Labs., Inc., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/080;
Stock Number PB90-245465
Additional Subjects Respiratory system ; Pathology ; Oils ; Fog ; Toxicology ; Lung ; Exposure ; Leukocytes ; Body weight ; Rats ; Reprints ; Respiratory function tests ; Macrophages ; Pulmonary alveoli ; Bronchoalveolar lavage fluid ; Organ weight
Library Call Number Additional Info Location Last
NTIS  PB90-245465 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 23p
Male rats were exposed to an oil fog generated by flash vaporization and subsequent condensation of lightweight lubricating oil. Exposures were for 3.5 h/d, 4d/wk for 13 wk, at concentrations of 1.5, 0.5, 0.2 or 0.0 mg/l (1500, 500, 200, and 0 mg/cu m) and a particle size of approximately 1 micro m (mass median aerodynamic diameter). A number of biologic endpoints were assessed the day after the last exposure and, in some cases, after a 4 wk recovery period. Effects of 1.5 mg/l on male and female rats were compared. Diffuse accumulation of macrophages in the alveoli was observed in all oil fog exposed groups. The degree of severity was concentration dependent. Histopathologic changes were more prominent in males than in females and represented the most notable gender-related differences. Histologic effects observed one day and 4 wk post exposure were similar. Minimal histopathologic changes and minimal increase in lavage fluid protein were the only effects observed at the 0.2 mg/l exposure level. There was a significant increase in lavage fluid protein, percent lavagable polymorphonuclear leukocytes and lung wet and dry weight following exposure to both 0.5 and 1.5 mg/l. (Copyright (c) 1990 Princeton Scientific Publishing Co., Inc.)