Record Display for the EPA National Library Catalog


Main Title Ozone Health Effects and Emerging Issues in Relation to Standards Setting.
Author Lippmann, M. ;
CORP Author New York Univ. Medical Center, NY. Inst. of Environmental Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA-R-811563; EPA/600/D-90/129;
Stock Number PB90-263294
Additional Subjects Ozone ; Respiratory system ; Exposure ; Exercise(Physiology) ; Seasonal variations ; Epidemiology ; Standards ; Reprints ; Air pollution effects(Humans) ; Airway resistance ; Health hazards ; Pulmonary alveoli ; Macrophages
Library Call Number Additional Info Location Last
NTIS  PB90-263294 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Our current knowledge of O3 exposure and health effects is growing rapidly. Transient respiratory function effects accumulate throughout an exposure day, and ambient exposures have broad daily peaks. O3 exposures also produce changes in airway inflammation and permeability. Healthy adults engaged for 1/2 hour in outdoor exercise show greater responses than those observed in chamber studies involving 1 or 2 hours of exposure, indicating potentiation of the O3 response by other environmental exposures. Acute animal studies show biochemical and structural responses to O3 are potentiated by co-exposure to NO2 and H2SO4. Chronic animal studies show that O3 effects on lung structure accumulate, and several recent epidemiological studies suggest that cumulative functional effects are occurring in people. Recent research has also shown: (1) a seasonal variation in functional responsiveness in humans; (2) that a seasonal pattern of daily exposure in monkeys produces greater changes in the lung than a continuous pattern of daily exposures at the same concentration; and (3) that transient exposures produce persistent responses. (Copyright (c) 1989 Elsevier Science Publishers B.V. Amsterdam.)