Record Display for the EPA National Library Catalog


Main Title High Doses of Aspartame Have No Effects on Sensorimotor Function or Learning and Memory in Rats.
Author Tilson, H. A. ; Hong, J. S. ; Sobotka, T. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;Food and Drug Administration, Washington, DC. Center for Food Safety and Applied Nutrition.
Publisher c30 Apr 90
Year Published 1990
Report Number EPA/600/J-91/008;
Stock Number PB91-177360
Additional Subjects Aspartame ; Learning ; Memory ; Psychomotor performance ; Rats ; Dose-response relationships ; Avoidance learning ; Spatial discrimination ; Startle reaction ; Statistical analysis ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB91-177360 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Acute or repeated (14 days) intragastric administration of L-d-aspartyl-L-phenyla-lanine methyl ester suspended in saline and Tween-80 in doses of up to 1,000 mg/kg had no significant effect in male Fischer-344 rats on routine measures of sensorimotor function, including spontaneous motor activity, acoustic startle reflex and prepulse inhibition. Other experiments found that aspartame (500 or 1,000 mg/kg) had no significant effect on acquisition of passive or active avoidance or a spatial, reference memory task in the Morris water maze. A series of separate studies found that aspartame had no effects in rats fasted 24 hours prior to testing, or if it were suspended in carboxymethylcellulose or administered by the intraperitoneal route. Under the conditions of these experiments, large doses of aspartame have no significant neurobiological effects in adult rats as measured by procedures known to be sensitive to the neurobiological effects of neurotoxicants, including convulsants, organochlorine insecticides and heavy metals.