Developing embryos of winter flounder, Pseudopleuronectes americanus, were exposed to 48 combinations of cadmium, salinity, and silver at 8.7C. Percentage of total hatch was at least 89% in all treatments while viable hatches ranged from 0 to 100%. Viable hatches decreased with increases in cadmium concentrations. The toxic effect of cadmium was greatest at 10% salinity and decreased significantly with each incremental increase in salinity level. Addition of silver to cadmium solutions also decreased the toxicity of the latter metal significantly. Silver exerted no lethal effect over the range of concentrations tested. Step-wise regression analysis shows that cadmium as well as interactions between cadmium and salinity, cadmium and silver, and silver and salinity significantly influenced the viable hatch response. Analyses of variance of viable hatch data indicate that each of those two-factor interactions was linear in nature.