Mass spectrometry : the foundation of proteomics / Timothy D. Veenstra -- Proteomic analysis by two-dimensional polyacrylamide gel electrophoresis / Pavel Gromov, Irina Gromova, Julio E. Celis -- Isotope labeling in quantitative proteomics / Kristy J. Brown, Catherine Fenselau -- Mass spectrometric characterization of post-translational modifications / Thomas P. Conrads, Brian L. Hood, Timothy D. Veenstra -- Technologies for large-scale proteomic tandem mass spectrometry / David L. Tabb, John R. Yates -- Protein fractionation methods for proteomics / Thierry Rabilloud -- Protein localization by cell imaging / Eric G.D. Muller, Trisha N. Davis -- Characterization of functional protein complexes / Leopold L. Ilag, Carol V. Robinson -- Structural proteomics by NMR / Marius Clore -- Protein microarrays / Cassio Da Silva Baptista, David J. Munroe -- Microfluidics-based proteome analysis / Yan Li, Don L. Devoe, Cheng S. Lee -- Single cell proteomics / Norman J. Dovichi, Shen Hu, David Michels, Danqian Mao, Amy Dambrowitz -- Diagnostic proteomics / Darue A. Prieto, Haleem J. Issaq -- Automation in proteomics / Timothy D. Veenstra -- Bioinformatics tools for proteomics / Daniel C. Liebler. Proteomics for biological discovery begins by discussing the emergence of proteomics from genome sequencing projects and a summary of potential answers to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are then dealt with in terms of underlying concepts, limitations and future directions. The book also provides a thorough overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, microfabrication, applied proteomics, and bioinformatics relevant to proteomics.