A data base was designed and constructed to organize and access data on the migration of chemical substances from polymeric materials. The data base was developed under an interagency agreement between the U.S. EPA and the FDA. The data base will facilitate the thorough and efficient review of chemical migration data and enable the EPA and FDA to maintain an up-to-date compilation of such data. The migration data base was developed using a commercial software package, Advanced Revelation, and runs on IBM personal computers and compatibles. Data elements include the identity of the polymer and migrant(s), the experimental conditions of the migration test, the diffusion coefficient, and the amounts migrated as a function of time, and the data source citation. Data extraction guidelines and data base features for data entry, editing, searching, and reporting were developed based on EPA/FDA operational requirements. All data entered into the data base were extracted from the published literature and FDA indirect food additive petition files. Migration data were entered from ninety citations and include data for 26 polymers and 81 migrants and adjuvants. A User Manual providing detailed user instructions was also prepared.