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Main Title Toxicity of Acetylenic Alcohols to the Fathead Minnow, 'Pimephales promelas': Narcosis and Proelectrophile Activation.
Author Veith, G. D. ; Lopnick, R. L. ; Russom, C. L. ;
CORP Author Environmental Research Lab.-Duluth, MN.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/084;
Stock Number PB90-103672
Additional Subjects Fishes ; Alcohols ; Toxicity ; Narcosis ; Electrophilic reactions ; Reprints ; Water pollution effects(Animals) ; Pimephales promelas ; Propargylic alcohols ; Homopropargylic alcohols ; Structure-activity relationship
Library Call Number Additional Info Location Last
NTIS  PB90-103672 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
The 96-h LC50 values for 16 acetylenic alcohols in the fathead minnow (Pimephales promelas) were determined using continuous-flow diluters. The measured LC50 values for seven tertiary propargylic alcohols agreed closely with the QSAR predictions based upon data for other organic non-electrolytes acting by a narcosis mechanism. Four primary and four secondary propargylic alcohols were 7 to 4600 times more toxic than the respective narcotic toxicity estimated by QSAR. Metabolic activation to electrophilic alpha, beta-unsaturated propargylic aldehydes or ketones is proposed to account for the increased toxicity. 3-Butyn-1-ol and 4-pentyn-2-ol, primary and secondary homopropargylic alcohols, were 320 and 160, respectively, times more toxic than predicted. In this case an activation step involving biotransformation to an allenic electrophile intermediate was proposed. (Copyright (c) 1989 Taylor and Francis, Ltd.)