Record Display for the EPA National Library Catalog


Main Title Influence of Cortisol on Prostaglandin Synthesis by Fetal Membranes, Placenta, and Uterus of Pregnant Rabbits (Journal Version).
Author Fail, P. A. ; Reynolds, R. P. ;
CORP Author North Carolina State Univ. at Raleigh. ;Research Triangle Inst., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1987
Year Published 1987
Report Number EPA/600/J-87/383;
Stock Number PB89-106827
Additional Subjects Fetal membranes ; Hydrocortisone ; Prostaglandins ; Prostaglandin synthase ; Uterus ; Placenta ; Laboratory animals ; Microsomes ; Induced abortion ; Amniotic fluid ; Pregnancy ; Progesterone ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB89-106827 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Two experiments were designed to assess the effects of cortisol on prostaglandin-forming cyclooxygenase in 4 gestational tissues of rabbits. Cortisol treatment (12 mg/kg body wt/h) was initiated on day 21 of pregnancy and continued for a 24-h period. In cortisol-treated rabbits, plasma progesterone decreased (P<.01) from 7.2 + or - 0.8 ng/ml on day 21 (pretreatment) to 1.6 + or - 0.2 ng/ml on day 23, 48 hrs after the initiation of cortisol treatment. By 62 h, PGF, PGE2, and cortisol concentrations were all significantly higher (P<.05) in the amniotic fluid of treated animals. However, cortisol treatment did not increase prostaglandin-forming cyclooxygenase activity in fetal or maternal tissues at either 48 or 62 h. Therefore, even though increased prostaglandin production may be responsible for the cortisol-induced abortion, increased cyclooxygenase activity in the gestational compartment was not detected.