Record Display for the EPA National Library Catalog


Main Title Dibutyl Phthalate: Maternal Effects versus Fetotoxicity (Journal Version).
Author Cummings, A. M. ; Gray, L. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1987
Year Published 1987
Report Number EPA/600/J-87/409;
Stock Number PB89-105555
Additional Subjects Ovum implantation ; Phthalates ; Toxic substances ; Toxicity ; Decidua ; Pregnancy ; Laboratory animals ; Uterus ; Organ weight ; Teratogens ; Ovary ; Females ; Progesterone ; Reprints ; Dibutyl phthalate ; Phthalic acid/dibutyl ester
Library Call Number Additional Info Location Last
NTIS  PB89-105555 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Dibutyl phthalate, a plasticizer, is a teratogen in mice and rabbits but produces fetal loss in the rat. Long-term dosing studies indicating reduced fertility in the rat suggested a maternal effect of the compound. The decidual cell response (DCR) and pregnant rats were used to examine whether DBP affects maternal physiological parameters independent of the compound's fetotoxic effect. DBP has no effect on the DCR, pregnant uterine weight, number of implantation sites, ovarian weight, or serum progesterone concentration during early pregnancy or pseudopregnancy. These data show that short term dosing with DBP has no direct maternal effect in the rat and suggest that the viability of preimplantation embryos is not compromised.