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Main Title Corpus luteum : animal models of possible relevance to reproductive toxicology /
Author Rao, Mrinalini, C. ; Gibori, G.
Other Authors
Author Title of a Work
Gibori, Geula.
CORP Author Abraham Lincoln School of Medicine, Chicago, IL.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher U.S. Environmental Protection Agency, Office of Health and Environmental Assessment,
Year Published 1988
Report Number EPA/600/J-88/290; OHEA-R-251
Stock Number PB89-202253
Additional Subjects Toxicity ; Reproduction(Biology) ; Progesterone ; In vivo analysis ; Reprints ; Corpus luteum ; Lutein cells ; Animal models
Library Call Number Additional Info Location Last
NTIS  PB89-202253 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12 pages ; 28 cm
The presence of a normally functioning corpus luteum is an essential requirement for the maintenance of gestation in mammals. The chief function of the corpus luteum in all species is to synthesize the steroid hormone progesterone that is necessary for implantation and for the subsequent development of the feto-placental unit. Activation and maintenance of luteal function involve pituitary, placental, and ovarian hormones. Perturbation in the secretion and/or action of any of these luteotropins by exogenous compounds can profoundly affect the steroidogenic capacity of the corpus luteum. Abnormal luteal function causes failure of implantation and embryonic wastage. Both in vitro and in vivo models for assessing luteal function are available; while the former are more convenient, the model of choice for toxicological studies is one in which in vitro findings can be easily confirmed in whole animals in vivo. The article is concerned primarily with the techniques used in basic research that might be useful for the evaluation of luteal function in reproductive toxicology. (Copyright (c) 1987 Pergamon Journals Ltd.)
"Journal article." "EPA/600/J-88/290." "Published in Reproductive Toxicology, 1(1), March 1988." Microfiche.