Record Display for the EPA National Library Catalog


Main Title Replacement of Estrogen by Methoxychlor in the Artificially-Induced Decidual Cell Response in the Rat.
Author Cummings, A. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div.
Publisher Feb 93
Year Published 1993
Report Number EPA/600/J-94/390;
Stock Number PB95-126546
Additional Subjects Estrogens ; Methoxychlor ; Pesticides ; Pharmacology ; Decidua ; Progesterone ; Rats ; Ovariectomy ; Dose-response relationships ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB95-126546 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
The pesticide methoxychlor (MXC) exhibits estrogenic activity although it is not a steriod. Therefore its mode of action may differ from that of estrogen. Here the author has evaluated the ability of MXC to replace estrogen in the ovariectomized, hormone-treated decidual cell response (DCR) model. Following priming with estrone, ovariectomized rats were treated with estrone plus progesterone, progesterone alone, or progesterone plus various dosage levels of MXC. Within a narrow dose range, MXC can replace estrone and, in combination with progesterone, produce a maximal DCR. In the same manner as that seen with progesterone plus estrone, progesterone plus MXC produced no effect different from progesterone alone at low to intermediate dosages and in inhibition of decidual growth at high doses. The data support the hypothesis that MXC exhibits classical mechanisms of estrongenic activity.