Four Federal agencies have outlined cooperative steps to curb the health and environmental threats posed by a group of toxic substances. In this report, OSHA, EPA, FDA, and CPSC describe the actions they have taken or plan to take in order to protect workers and the general public from disease and illness caused by the unsafe manufacture, handling, and use of twenty-four compounds. These compounds range from the plastic material, acrylonitrile, to radiation to toxic waste disposal. Acting under a year old cooperative agreement which created the Interagency Regulatory Liaison Group (IRLG), the member agencies are pooling their knowledge and resources to promote the development of the most efficient health protection programs with the least cost to the regulated industries.