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RECORD NUMBER: 104 OF 219

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Main Title

Initial Submission: Toxicity Studies of 1-Isocyanato-2-Methoxybenzene with Cover Letter dated 09/08/1992.

CORP Author

Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.

Year Published

1992

Report Number

8EHQ-0992-10991

Stock Number

OTS0571029

Additional Subjects

Toxicology ; Health effects ; Toxic substances ; 1-isocyanato-2-methoxybenzene ; Acute toxicity ; Mammals ; Rats ; Inhalation ; Primary eye irritation ; Rabbits ; Dermal ; Oral ; Gavage ; Guinea pigs ; CAS No 700-87-8

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	OTS0571029	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

Abstract

The report pertains to 1-isocyanato-2-methoxybenzene (synonym: o-methoxyphenyl isocyanate) (CAS No. 700-87-8) and is being submitted because of lethality observed in an acute inhalation toxicity test in rats. The 6-hour LCs is less than 1.38 mg/L. The test material is a severe eye irritant. Testicular atrophy with localized tubular atrophy, necrosis, and mineralization was observed in a rat following a single oral dose of 1,600 mg/kg. The significance of these lesions is unclear. The report is being identified as a study involving other than human effects (Unit II.B.2.b ofCAP Agreement).

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