||Initial Submission: Acute Oral Toxicity and Skin Absorption and Irritation of 3-Chloropropionitrile in Rats and Guinea Pigs with Cover Letter dated 08/26/1992.
||Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Acute toxicity ;
Primary dermal irritation ;
Guinea pigs ;
CAS No 542-76-7
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The report pertains to 3-chloropropanenitrile (synonym: 3-chloropropionitrile) (CAS No. 542-76-7) and is being submitted because of lethality with central nervous system (CNS) signs observed in an acute oral toxicity study in rats. The oral LD50 is 10-50 mg/kg in rats. The material is also a slight skin irritant. The dermal LD50 is 0.05-0.1 cc/kg in guinea pigs. The report is being identified as a study involving other than human effects (Unit II.B.2.b of CAP Agreement).