Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Critical Prenatal Periods for Chlorambucil-Induced Functional Alterations of the Rat Kidney.
Author Kavlock, R. J. ; Rehnberg, B. F. ; Rogers, E. H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/033;
Stock Number PB87-198388
Additional Subjects Kidney ; Pregnancy ; Toxicity ; Rats ; Congenital abnormalities ; Reprints ; Chlorambucil ; Prenatal exposure delayed effects ; Neonatal diseases and abnormalities ; Abnormalities(Drug induced) ; Enviromental pollutants
Library Call Number Additional Info Location Last
NTIS  PB87-198388 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 16p
Previous studies have demonstrated that exposure of rats to chlorambucil during the period of metanephric differentiation results in morphological and functional alterations of the kidneys after birth. The present study describes the effects of chlorambucil treatment at various gestational ages on neonatal renal function. The results demonstrate that the critical period for the induction of specific renal defects and hypoplasia lies on day 11 of gestation, but functional alterations of the kidneys were observed after exposure on day 15 of gestation.