Record Display for the EPA National Library Catalog
RECORD NUMBER: 2 OF 4
|OLS Field Name||OLS Field Data|
|Main Title||Initial Submission: The Toxicity and Potential Dangers of Polyvinyl Alcohols RH-276 and RH-394 and Polyvinyl Acetate Rh-207-U150 with Cover Letter dated 10/15/1992.|
|CORP Author||Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Polyvinyl alcohols ; Polyvinyl acetate ; Subchronic toxicity ; Mammals ; Rats ; Dermal ; Cats ; Oral ; Diet ; Parenteral ; Intraperitoneal ; Rabbits ; Inhalation ; CAS No 9002-89-5 ; CAS No 9003-20-7|
Two groups of ten rats each were dehaired on the back and five times a week for eight weeks 3 cc. of a four per cent solution of each of the polyvinyl alcohols was applied to the dehaired skin, amounting to a total daily application of 120 mg. The rats appeared normal throughout the entire experiment, but the hair grew very slowly and unevenly, and in some animal no new hair grew during the treatment. Although there was apparently some retardation of the growth of the hair, there was no evidence of a toxic effect on the hair follicles, because one week after the last treatment the backs of all rats showed an even growth of the hair.