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RECORD NUMBER: 27 OF 64

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Main Title

Evaluation of the Mutagenic Potentials of Platinum Compounds.

Author

Sandhu, Shahbeg ;

CORP Author

North Carolina Central Univ., Durham. Dept. of Biology.;Health Effects Research Lab., Research Triangle Park, NC.

Year Published

1979

Report Number

EPA-R-803299; EPA-600/1-79-033;

Stock Number

PB81-228181

Additional Subjects

Mutagens ; Platinum inorganic compounds ; Environmental surveys ; Toxicology ; Metals ; Evaluation ; Mice ; Bioassay ; Mutagenesis ; Cell lines ; Toxic substances ; Platinum diaminodichloride ; Platinum diaminodinitrite ; Platinum dichloride ; Platinum tetrachloride

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB81-228181	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

41p

Abstract

Five platinum compounds, cis-platinum diaminodichloride (cis-PDD), trans-platinum diaminodichloride (trans-PDD), platinum diaminodinitrite, platinum dichloride (PtCl2), and platinum tetrachloride (PtCl4) were evaluated for their mutagenic activity at the thymidine kinase locus in the mouse lymphoma cells line L5178Y. Three of these compounds, i.e., cis-PDD, trans-PDD and PtCl4 yielded significantly higher mutagenic frequencies as compared to the control. Two platinum compounds, i.e., cis-PDD and PtCl4, were also judged to be mutagenic on the basis of results obtained in the Phaseolus mungo plant test system.

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