Record Display for the EPA National Library CatalogRECORD NUMBER: 1 OF 1
|Main Title||Evaluation of the Mutagenic Potentials of Platinum Compounds.|
|Author||Sandhu, Shahbeg ;|
|CORP Author||North Carolina Central Univ., Durham. Dept. of Biology.;Health Effects Research Lab., Research Triangle Park, NC.|
|Report Number||EPA-R-803299; EPA-600/1-79-033;|
|Additional Subjects||Mutagens ; Platinum inorganic compounds ; Environmental surveys ; Toxicology ; Metals ; Evaluation ; Mice ; Bioassay ; Mutagenesis ; Cell lines ; Toxic substances ; Platinum diaminodichloride ; Platinum diaminodinitrite ; Platinum dichloride ; Platinum tetrachloride|
Five platinum compounds, cis-platinum diaminodichloride (cis-PDD), trans-platinum diaminodichloride (trans-PDD), platinum diaminodinitrite, platinum dichloride (PtCl2), and platinum tetrachloride (PtCl4) were evaluated for their mutagenic activity at the thymidine kinase locus in the mouse lymphoma cells line L5178Y. Three of these compounds, i.e., cis-PDD, trans-PDD and PtCl4 yielded significantly higher mutagenic frequencies as compared to the control. Two platinum compounds, i.e., cis-PDD and PtCl4, were also judged to be mutagenic on the basis of results obtained in the Phaseolus mungo plant test system.