||Regional Patterning of Hormones in the Female Rat Anterior Pituitary: Disproportionate Changes Over the Estrous Cycle.
Goldman, J. M. ;
Cooper, R. L. ;
Rehnberg, G. L. ;
Booth, K. C. ;
McElroy., W. K. ;
||Health Effects Research Lab., Research Triangle Park, NC. Toxicology Branch. ;Northrop Services, Inc., Research Triangle Park, NC.
Diurnal variations ;
Anterior pituitary hormones ;
Pituitary hormone releasing hormones ;
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The study addressed the possibility that regional differences exist in the typical patterning of anterior pituitary hormones seen over the estrous cycle. The results show that LH in the rostral area of the pituitary, significantly higher than in other regions on diestrus, rises markedly on proestrus before falling late on that afternoon to concentrations comparable to other areas. Smaller cyclic changes were seen for lateral and caudo-central areas. The pattern of regional FSH concentrations on diestrus, while similar to LH, does not show the proestrus fall in the rostral region. Prolactin declines from a high on diestrus I to a low on late proestrus, but no regional disparities are present. TSH shows distinct regional differences and a fall in concentrations that coincides with the reported rise in serum estradiol. (Copyright (c) 1989 by Marcel Dekker, Inc.)