Record Display for the EPA National Library Catalog


Main Title Brain-Acetylcholinesterase Inhibition in a Marine Teleost during Lethal and Sublethal Exposures to 1,2-Dibromo-2,2-dichloroethyl Dimethyl Phosphate (Naled) in Seawater.
Author Coppage, David L. ; Matthews., Edward ;
CORP Author Environmental Protection Agency, Gulf Breeze, Fla. Gulf Breeze Environmental Research Lab.
Year Published 1974
Report Number GULF BREEZE CONTRIB-199;
Stock Number PB-280 834
Additional Subjects Pesticides ; Cholinesterase inhibitors ; Insecticides ; Toxicology ; Phosphorus organic compounds ; Exposure ; Lethal dosage ; Bromine organic compounds ; Chlorine organic compounds ; Fishes ; Toxic diseases ; Bioassay ; Physiological effects ; Marine fishes ; Sublethal dosage ; Brain ; Lagodon rhomboides ; Reprints ; Naled ; Toxic substances ; Teleostes ; Pinfish ; Water pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB-280 834 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
To determine if brain-acetylcholinesterase (AChE) inhibition in a marine teleost Lagodon rhomboides (pinfish) by an organophosphate pesticide (naled) is specific enough to diagnose anticholinesterase poisoning, brain-AChE inhibition by sublethal exposure in seawater was compared to brain-AChE inhigition caused by lethal exposure. A sublethal exposure did not inhibit brain-AChE as much as lethal exposure in periods of 24, 48, and 72 hr. Consistent levels of inhibition (84-89% inhibition) occurred when 40-60% of an exposed populaion of pinfish was killed. This correlation of brain-AChE inhibition with exposure and death in a fish population shows that brain-AChE measurements are of value in diagnosing anticholinesterase poisoning in a marine fish.