Record Display for the EPA National Library Catalog

RECORD NUMBER: 690 OF 1964

Main Title Evaluation of the potential carcinogenicity of N-Nitroso-N-Methyurethane (615-53-2) /
CORP Author Syracuse Research Corp., NY. ;Environmental Monitoring and Services, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ;
Year Published 1988
Report Number EPA-68-03-3112; EPA-68-03-3182; EPA/600/8-91/165; OHEA-C-073-153
Stock Number PB93-196491
Subjects N-Nitroso-N-Methylurea--Carcinogenicity
Additional Subjects Nitrosomethylurethane ; Toxicity ; Risk assessment ; Public health ; Exposure ; Hazardous materials ; Neoplasms ; Tolerances(Physiology) ; Carcinogenicity ; Dose-response relationships ; CAS: 615-53-2
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB93-196491 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 29 pages ; 28 cm
Abstract
N-Nitroso-N-methylurethane is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is 'Sufficient', and the evidence from human studies is 'No Data'. The results of the bioassay for N-nitroso-N-methylurethane suggest that the substance is highly potent, but because all treated animals developed tumors, there is no basis for designing a specific human potency factor (F). Therefore, N-nitroso-N-methylurethane is assigned to the high potency factor range and placed in potency group 1, under the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency information, N-nitroso-N-methylurethane is assigned a 'HIGH' hazard ranking.
Notes
Cover title. "June 1988." Includes bibliographical references. Microfiche.