Introduction to pathophysiology concepts -- Homeostasis and adaptive responces to stressors -- Cell structure and function -- Cell injury, aging, and death -- Molecular genetics and tissue differentiation -- Genetic and developmental disorders -- Neoplasia -- Infectious processes -- Inflammation and immunity -- Alternations in immune function -- Malignant disorders of white blood cells -- HIV disease and AIDS -- Alterations in oxygen transport -- Alterations in hemostasis and blood coagulation -- Alterations in blood flow -- Alterations in blood pressure -- Cardiac function -- Alterations in cardiac function -- Heart failure and dysrhythmias: common sequelae of cardiac diseases -- Shock -- Respiratory function and alterations in gas exchange -- Obstructive pulmonary disorders -- Restrictive pulmonary disorders -- Fluid and electrolyte homeostasis and imbalances -- Acid-base homeostasis and imbalances -- Renal function -- Intrarenal disorders -- Acute renal failure and chronic kidney disease -- Disorders of the lower urinary tract -- Male genital and reproductive function -- Alterations in male genital and reproductive function -- Female genital and reproductive function -- Alterations in female genital and reproductive function -- Sexually transmitted infections -- Gastrointestinal function -- Gastrointestinal disorders -- Alterations in function of the gallbladder and exocrine pancreas -- Liver diseases -- Endocrine physiology and mechanisms of hypothalamic-pituitary regulation -- Disorders of endocrine function -- Diabetes mellitus -- Alterations in metabolism and nutrition -- Structure and function of the nervous system -- Acute disorders of brain function -- Chronic disorders of neurologic function -- Alterations in special sensory function -- Pain -- Neurobiology of psychotic illnesses -- Neurobiology of nonpsychotic illnesses -- Structure and function of the musculoskeletal system -- Alterations in musculoskeletal function: trauma, infection, and disease -- Alterations in musculoskeletal function: rheumatic disorders -- Alterations in the integumentary system -- Burn injuries. With dynamic full-color illustrations and an easy-to-read writing style, this 4th Edition explores the etiology, pathogenesis, clinical manifestation, and treatment of disease. Each unit covers a specific body system and begins with an illustrated review of anatomy and normal physiology to prepare you for disease processes and abnormalities discussions. Coverage of the latest developments in pathophysiology and a wealth of student-friendly learning resources will help you understand all of the major degenerative, neoplastic, metabolic, immunologic and infectious diseases. Highlighted Key Points focus you on the most important information. Additional content on the Companion CD and the companion Evolve website provide more opportunities for learning with case study worksheets, additional exercises, animations, and much more. Revised content includes the most current information and research on RNA molecules in cell function, guidelines, heart failure, alzheimers, and more to keep you at the cutting-edge of pathophysiology. A new focus on general introductory principles and data measurement in clinical practice provides a solid beginning to pathophysiology study.