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RECORD NUMBER: 15 OF 15

OLS Field Name OLS Field Data
Main Title Support: Science of Organic Fluorochemistry and Perfluorooctane Sulfonate; Current Summary of Human Sera, Health and Toxicology Data, with Cover Letter dated 02/05/1999.
CORP Author Hazleton Labs. America, Inc., Madison, WI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 8EHQ-0299-0373
Stock Number OTS0204929-6
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Fluorine ; Environmental fate ; Physical/chemical properties ; Perfluorooctane sulfonate ; Laboratory animals ; Reproduction/fertility effects ; Teratogenicity ; Mammals ; Rats ; Oral ; Gavage ; CAS No 7782-41-4 ; CAS No 2795-39-3
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NTIS  OTS0204929-6 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 04/28/2010
Collation 258p
Abstract
Potassium perfluorooctane sulfonate (CAS 2795-39-3) was evaluated for development toxicity in female Sprague-Dawley CD rats (25/group)administered doses of 1, 5, mg/kg/day by oral gavage on presumed Gestation Days 6-15. Clinical signs of mate toxicity included emaciation (1, 5, 10 mg/kg/day), hunched posturing (5, 10 mg/k lopecia)(5, 10 mg/kg/day), rough haircoats (5, 10 mg/kg/day), anorexia (10 mg/k mortality)(2/25, 10 mg/kg/day). Both food consumption and bodyweight gain were in mid- and high-dose groups and adjusted terminal bodyweights (minus gravidute weights) were also significantly below those of controls. Gross pathology was lesions of the gastrointestinal tract in 10 mg/kg/day dams. Reproductive effects related fetal loss by resorption and dead fetuses in litters (10 mg/kg/day) and significant (p < 0.05) decreases in male and female fetal bodyweights. Subcutane cleft palate, and cryptorchism characterized the toxicologically significant extravisceral aberrations in fetuses in the 10 mg/kg/day dams. Skeletal ossification delayed in the fetuses of this group as was indicated by significantly increased girdle, rib cage, vertebral column, pelvic girdle, and limb variants. Document includes: Support: Rat Teratology Study T-3351 (with Perfluorooctane Sulfonate), Final Report, with Cover Letter dated 3/15/1999.