Record Display for the EPA National Library Catalog

RECORD NUMBER: 19 OF 25

Main Title Poisoning by Organic Phosphorus Pesticides Potentiated by Phenothiazine Derivatives.
Author Gaines., Thomas B. ;
CORP Author Communicable Disease Center, Atlanta, Ga.
Year Published 1962
Stock Number PB-280 840
Additional Subjects Toxicology ; Pesticides ; Toxicity ; Phosphorus organic compounds ; Dosage ; Rats ; Males ; Females ; Concentration(Composition) ; Lethal dosage ; Mortality ; Bioassay ; Survival ; Ingestion(Biology) ; Laboratory animals ; Experimental data ; Sulfur organic chemicals ; Chlorpromazine ; Reprints ; Parathion ; Toxic substances ; Phosphorothioic acid/O-O-(dimethyl-ester)-O-(nitrophenyl-ester) ; Promazine ; Phenothiazine/((dimethyl-amino)propyl) ; Phenothiazine/chloro-((dimethyl-amino)propyl)
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB-280 840 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 2p
Abstract
Repeated administration of the phenothiazine derivative chlorpromazine and promazine increased the toxicity of a single dose of parathion in male rats. In female rats, a single dose of 5 mg/kg of promazine increased the toxicity of a single dose of parathion, but had no apparent effect on the toxicity of a single dose of Phosdrin. Repeated dosage with chlorpromazine and atropine, or promazine and atropine, after administration of parathion at the same rate, resulted in a slightly higher mortality in female rats than did atropine or no treatment.