Record Display for the EPA National Library CatalogRECORD NUMBER: 19 OF 25
|Main Title||Poisoning by Organic Phosphorus Pesticides Potentiated by Phenothiazine Derivatives.|
|Author||Gaines., Thomas B. ;|
|CORP Author||Communicable Disease Center, Atlanta, Ga.|
|Stock Number||PB-280 840|
|Additional Subjects||Toxicology ; Pesticides ; Toxicity ; Phosphorus organic compounds ; Dosage ; Rats ; Males ; Females ; Concentration(Composition) ; Lethal dosage ; Mortality ; Bioassay ; Survival ; Ingestion(Biology) ; Laboratory animals ; Experimental data ; Sulfur organic chemicals ; Chlorpromazine ; Reprints ; Parathion ; Toxic substances ; Phosphorothioic acid/O-O-(dimethyl-ester)-O-(nitrophenyl-ester) ; Promazine ; Phenothiazine/((dimethyl-amino)propyl) ; Phenothiazine/chloro-((dimethyl-amino)propyl)|
Repeated administration of the phenothiazine derivative chlorpromazine and promazine increased the toxicity of a single dose of parathion in male rats. In female rats, a single dose of 5 mg/kg of promazine increased the toxicity of a single dose of parathion, but had no apparent effect on the toxicity of a single dose of Phosdrin. Repeated dosage with chlorpromazine and atropine, or promazine and atropine, after administration of parathion at the same rate, resulted in a slightly higher mortality in female rats than did atropine or no treatment.