Record Display for the EPA National Library Catalog


Main Title Parathion Toxicity in Perinatal Rats Exposed in Utero.
Author Deskin, R. ; Rosenstein, L. ; Rogers, N. ; Westbrook, B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Year Published 1979
Report Number EPA/600/J-79/007;
Stock Number PB-294 858
Additional Subjects Toxicology ; Pesticides ; Females ; Rats ; Pregnancy ; Insecticides ; Physiological effects ; Experimental data ; Exposure ; Cholinesterase inhibitors ; Bioassay ; Renin ; Males ; Phosphorus organic compounds ; Reprints ; Lactation ; Fetuses ; Parathion ; Toxic substances ; Phosphorothioic acid/O-O-(dimethyl-ester)-O-(nitrophenyl-ester)
Library Call Number Additional Info Location Last
NTIS  PB-294 858 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Adult pregnant female rats were exposed to subchronic doses of parathion throughout gestation and lactation. Their offspring were examined for possible toxicological effects. This study found that several physiological parameters were affected. Female perinates exhibited a significant reduction in plasma cholinesterase (pseudo ChE) activity. Plasma renin activity was reduced with increased dose of parathion in both male and female perinates. Heart rate, QRS complex duration, S-T and P-R intervals were all reduced in the perinates. The results of this study indicated that physiological function can be altered by organophosphate exposure at levels lower than those required to show pseudo ChE inhibition.