Record Display for the EPA National Library Catalog
RECORD NUMBER: 3 OF 26Main Title | Acute Toxicity of Monochlorophenols, Dichlorophenols and Pentachlorophenol in the Mouse. | |||||||||||
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Author | Borzelleca, J. F. ; Hayes, J. R. ; Condie, L. W. ; Egle, J. L. ; | |||||||||||
CORP Author | Medical Coll. of Virginia, Richmond. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Cincinnati, OH. | |||||||||||
Year Published | 1985 | |||||||||||
Report Number | EPA-R-808861; EPA/600/J-85/352; | |||||||||||
Stock Number | PB86-175478 | |||||||||||
Additional Subjects | Toxicity ; Phenols ; Bioassay ; Mice ; Laboratory animals ; Dosage ; Chlorine organic compounds ; Reprints ; Phenol/dichloro ; Phenol/monochloro ; Phenol/pentachloro | |||||||||||
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Collation | 6p | |||||||||||
Abstract | Acute oral LD50 values were determined for 2-, 3-, and 4-chlorophenol; 2,3-, 2,4-, 2,5-, 2,6-, 3,4-, and 3,5 dichlorophenol and pentachlorophenol in male and female mice. LD50 values (mg/kg) ranged from 117 (females) and 177 (males) for pentachlorophenol to 2389 (females) and 2643 (males) for 3,5-dichlorophenol. It was found that 2-chlorophenol and 3-chlorophenol were considerably more toxic than the dichlorophenol series. Values for males and females were generally similar, the major differences being with pentachlorophenol and 2,5-dichlorophenol where in both cases the female LD50 was lower. |