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RECORD NUMBER: 25 OF 26

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Main Title

Use of 'In vitro' Methods for Assessing Reproductive Toxicity, Dichlorophenols.

Author

Seyler, D. E. ; East, J. M. ; Condie, L. W. ; Borzelleca, J. F. ;

CORP Author

Medical Coll. of Virginia, Richmond. Dept. of Pharmacology. ;Georgetown Univ., Washington, DC.;Health Effects Research Lab., Research Triangle Park, NC.

Year Published

1984

Report Number

EPA-R-808861; EPA/600/J-84/127;

Stock Number

PB85-113975

Additional Subjects

In vitro analysis ; Toxicity ; Phenols ; Reproductive system ; Laboratory animals ; Public health ; Assessments ; Concentration(Composition) ; Chlorine organic compounds ; Dosage ; Reprints ; Phenol/dichloro

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB85-113975	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

11p

Abstract

Environmental levels of dichlorophenols (DCPs) appear to be increasing. A paucity of knowledge exists concerning the impact of these agents on human health, including reproductive effects. Mice are being exposed to various DCPs to determine their toxic potential. In addition, the mouse in vitro fertilization method ass used to evaluate the potential reproductive effects of series of DCPs. This method is preliminary reproductive screening procedure. In vitro penetration was depressed by 2,5-DCP, 3,4-DCP, and 3,5-DCP. None of the agents affected sperm motility. Acridine orange fluorescent microscopy revealed that 3,4-DCP and 3,5-DCP disrupted the sperm acrosome; this could result in depressed penetration.

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