Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Adsorption, Distribution, Metabolism and Excretion of Cyclohexane (June 1984).
CORP Author Research Triangle Inst., Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 40-8423127
Stock Number OTS0527475
Additional Subjects Toxicology ; Health effects ; Cyclohexane ; Pharmaco Kinetics ; Mammals ; Rats ; Parenteral ; Intravenous ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 110-82-7
Library Call Number Additional Info Location Last
NTIS  OTS0527475 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 70p
The pharmacokinetics of cyclohexane was studied in adult male Fischer 344 rats administered 10 mg/kg 14C-cyclohexane by intravenous injection. At 72 hours, the concentration of 14C in adipose averaged 16 times that in blood. Cyclohexane accounted for 79 to 84% of the radiolabel in adipose, but only 1 to 18% of it in muscle, liver and skin. Small amounts of cyclohexanone and cyclohexanol accounted for the remainder of the C14 present. Most of the radiolabel was excreted in the breath (54% in the 1st hour; 80% in 24 hours, and 83% in 72 hours), 14% in urine, and trace amounts in feces. After oral administration of 2000, 1000, 200, or 100 mg/kg of 14C-cyclohexanone to rats , 78, 76, 62, and 63% C14, respectively, was eliminated in the breath, and 12, 15, 29, and 29% in urine. Again, trace amounts of C14 were eliminated in feces. Three major urinary metabolites, apparently conjugated forms that constituted approximately 1 to 15% of the radioactive dose, were observed but not characterized. Plasma content of 14C was fairly constant (approximately 9.0 to 14.1 ug-eq/g of plasma) from 2 to 12 hours post treatment, but decreased to about 20% of this by 24 hours. Cyclohexane, cyclohexanone, and cyclohexanol accounted for most of the plasma 14C at 6 to 24 hourspost-dosing. At least 5 other unidentified metabolites were found (at 14C-concentrations ranging from approximately 0.14 to 0.74 ug-eq/g at 24 hours). Distribution followed the same pattern after oral dosing as after intravenous administration. The half-lives of total 14C in plasma and tissues, including adipose, were generally about 10 to 15 hours.