Record Display for the EPA National Library Catalog
RECORD NUMBER: 48 OF 78
|OLS Field Name||OLS Field Data|
|Main Title||Metabolism of 2-chloro'u-ring-14c/toluene by Rats Dosed Intravenously.|
|CORP Author||Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; 2-chlorotoluene ; Pharmaco Kinetics ; Mammals ; Rats ; Parenteral ; Intravenous ; Toxic substances ; Laboratory animals ; CAS No 95-49-8|
The metabolism of 2-chlorotoluene was examined in 4 female rats (strain not reported) injected intravenously with a single 0.7 mg/kg dose of (U-ring-14C)2-chlorotoluene. Rats eliminated 69-81% and 14-18% of the applied dose in the urine and as expired volatiles, respectively, within 4 days after dosing. Nearly all of the volatile 14C in expired air was 2-chlorotoluene. The primary urinary metabolites were mercapturic acid, glucuronide, and 2- chlorohippurate, representing 22-24, 13-20, and 7-11% of urinary 14C, respectively.