Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Letter from Chemical Manufacturers Association to US EPA Submitting Enclosed Final and Interim Reports on 2-ethylhexanoic Acid with Attachments.
CORP Author Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 40-8797187
Stock Number OTS0525556
Additional Subjects Toxicology ; Health effects ; 2-ethylhexanoic Acid ; Acute Toxicity ; Mammals ; Rats ; Oral ; Gavage ; Primary Dermal Irritation ; Dermal ; Pharmaco Kinetics ; Subchronic Toxicity ; Mice ; Toxic substances ; Laboratory animals ; CAS No 149-57-5
Library Call Number Additional Info Location Last
NTIS  OTS0525556 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 54p
2-Ethylhexanoic acid (EHA) was evaluated for acute toxicity to female Fischer F-344 rats (4/group) exposed to single oral doses of 0, 100, 800, 1600, or 3200 mg/kg of EHA administered in corn oil by gavage. Animals were observed for 14 days prior to necropsy. Mortality (4/4) occurred within 24 hours at the high- dose. Transitory weakness was observed in lower-dose animals. The acute oral LD50 for rats was 2043 (1445 to 2890) mg/kg. Preliminary data summaries of the following studies are presented: 1) A dermal irritation test with female rats exposed for 96 hours to 1 g/kg of undiluted EHA under occlusion; serious damage was seen in epidermal tissues within 24 hours. 2) Pharmacokinetic studies with rats orally exposed to 0.1 or 1.0 g/kg by gavage; urinary excretion accounted for 80% of each dose by 96 hours post- treatment, while fecal excretion accounted for about 12% of the low dose and 6% of the high-dose. Several metabolites were separated, but not identified. 3) 14-Day oral toxicity probe studies with mice and rats exposed to 0, 200, 800, or 1600 mg/kg/day EHA by gavage; 1600 mg/kg/day was lethal to rats, and 800 mg/kg/day led to decreased weight gain in males and increased liver weights in both sexes. In mice, there were slight changes in liver weights of high-dose animals. The NOAEL for mice was 800 mg/kg/day, and for rats, 200 mg/kg/day.