Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Final Report on the Acute Inhalation Metabolism Study of Cyclohexanone in Rats with Cover Letter Dated 05/13/1987.
CORP Author Industrial Health Foundation, Inc., Pittsburgh, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1987
Report Number 86870000330
Stock Number OTS0513079
Additional Subjects Toxicology ; Health effects ; Cyclohexanone (108-94-1) ; Pharmaco Kinetics ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 108-94-1
Library Call Number Additional Info Location Last
NTIS  OTS0513079 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 73p
Metabolism of cyclohexanone was evaluated in groups of 5 young adult male Sprague-Dawley rats exposed by inhalation to the test article at time-weighted concentrations of 350 or 1479 ppm for 6 hours (determined by gas chromatography). The animals lost weight and exhibited sedation. The material was rapidly eliminated from the blood; concentrations of free cyclohexanone and cyclohexanol in the blood immediately after exposure were approximately 26.01 and 20.48 ug/ml, respectively, at the low-dose and 121.76 and 140.43, respectively, at the high-dose whereas only trace quantities of free cyclohexanol were observed at 24 hours. The total 72 h urinary excretion volumes of free cyclohexanone and cyclohexanol were 16.16 and 14.55 ug, respectively, at the low-dose and 142.93 and 264.08 ug, respectively, at the high-dose. By 72 hours, the excretion of conjugated cyclohexanol (primarily excreted during the first 24 hours) and a conjugated product tentatively identified as cyclohexanone occurred at levels of 13,306.15 and 546.69 ug, respectively, at the low-dose and 72,446.56 and 890.94 ug, respectively, at the high-dose.