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RECORD NUMBER: 69 OF 78

Main Title Support: Letter from Dupont to USEPA with Summary and Results of a Two-Week Inhalation Toxcity Study with 1,N-Diiodoperfluoroalkanes in Rats, dated 05/07/2002.
CORP Author Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2002
Report Number 8EHQ-0502-13829
Stock Number OTS0559066-3
Additional Subjects Toxicology ; Health effects ; Toxic substances ; 1-N-diiodoperfluoroalkanes ; Subchronic toxicity ; Mammals ; Rats ; Inhalation ; Pharmaco kinetics ; CAS No 375-50-8 ; CAS No 375-80-4
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NTIS  OTS0559066-3 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Abstract
Groups of male rats were exposed 6 hours daily for 2 weeks (9 exposures) via inhalation to 0, 0.1, 2.5, or 25 ppm of the test material. The exposure period was followed by a 2-week recovery period. Rats were weighed and observed for clinical signs on a daily basis. Food consumption was determined on a weekly basis. Clinical pathology and anatomic pathology evaluations were conducted on rats at the end of the exposure and recovery periods. One day following the final exposure, serum levels of thyroid stimulating hormone (TSH), triiodothyronine (Ts), and thyroxine (Ta) were measured in all rats. Rats exposed at 2.5 or 25 ppm had significantly lower mean body weights during the exposure and recovery phases and significantly lower mean body weight gains, food consumption, and food efficiency during the exposure period. No clinical signs of toxicity attributable to exposure to the test material were observed.