| Main Title |
The in-vivo metabolism of pentachloroaniline in rhesus monkeys / |
| Author |
Leber, A. Philip. ;
Freudenthal., R. I.
|
| Other Authors |
|
| CORP Author |
United States. Environmental Protection Agency. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory |
| Year Published |
1976 |
| Report Number |
EPA-600/1-76-031; EPA-68-02-1715 |
| Stock Number |
PB 259 929 |
| OCLC Number |
48644170 |
| Subjects |
Pesticides--toxicity ;
Neurotoxins ;
Pesticides--toxicity--Congresses
|
| Additional Subjects |
Isotopic labeling ;
Fungicides ;
Toxicology ;
Amines ;
Chlorine organic compounds ;
In vivo analysis ;
Tables(Data) ;
Rhesus monkeys ;
Metabolism ;
Laboratory animals ;
Dosage ;
Absorption(Biology) ;
Physiological effects ;
Pesticides ;
Pharmacology ;
Aniline/pentachloro ;
Metabolites
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-76-031 |
|
Headquarters Library/Washington,DC |
04/08/2014 |
| EKBD |
EPA-600/1-76-031 |
|
Research Triangle Park Library/RTP, NC |
06/20/2003 |
| ELBD ARCHIVE |
EPA 600-1-76-031 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD |
EPA 600-1-76-031 |
|
AWBERC Library/Cincinnati,OH |
03/01/2021 |
| NTIS |
PB-259 929 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
iv, 33 pages : illustrations ; 28 cm. |
| Abstract |
The metabolism of pentachloroaniline was determined in the rhesus monkey. 14C-pentachloroaniline was orally administered to five rhesus monkeys. Blood, urine and feces were collected at designated times following dosing. The radioactive material in the biological samples was extracted and then separated by chromatographic procedures. The chemical structure of the major metabolite was characterized by mass spectrometry and nuclear magnetic resonance spectrometry, using a chemically synthesized reference standard. Radioactivity levels in the blood samples indicate large variation between individual animals with respect to rate of absorption and time of peak plasma radioactivity. Urinary excretion accounts for 33 to 67 percent of the administered dose while from 6 to 15 percent is excreted in the feces. |
| Notes |
"Contract No. 62-02-1715." "Project officer, Dr. Ronald L. Baron." "EPA-600/1-76-031." "September 1976." Includes bibliographical references. |
