Record Display for the EPA National Library Catalog

RECORD NUMBER: 446 OF 919

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Main Title

Kepone-Induced Scoliosis and Its Histological Consequences in Fish.

Author

Couch, John ; Winstead, James ; Goodman., Larry ;

CORP Author

Environmental Research Lab., Gulf Breeze, Fla.

Year Published

1977

Report Number

EPA/600/J-77/077;

Stock Number

PB-277 182

Additional Subjects

Fishes ; Scoliosis ; Insecticides ; Pesticides ; Toxicology ; Toxic diseases ; Chlorine organic compounds ; Minnows ; Nervous system ; Pathology ; Musculosketal disorders ; Central nervous system ; Histology ; Aquatic animals ; Experimental data ; Reprints ; Kepone ; Laboratory tests

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB-277 182	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

Abstract

Scoliosis in fish is caused by several diverse agents that possibly act on the central nervous system, neuromuscular junctions, or ionic metabolism. The organochlorine pesticide Kepone induces scoliosis in the sheepshead minnow. Some effects associated with Kepone-induced scoliosis in these fish are disruption of myotomal patterns, inter- and intramuscular hemorrhage, fractured centra of vertebrae, and death. The histological syndrome of Kepone poisoning in fish and the clinical syndrome in humans suggest that the nervous system is a primary target for Kepone and that scoliosis is a secondary effect of Kepone poisoning in fish.

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