| Main Title |
Effects of Exposure to Peroxyacetyl Nitrate on Susceptibility to Acute and Chronic Bacterial Infection. |
| Author |
Thomas, Gail B. ;
Fenters, James D. ;
Ehrlich, R. ;
Gardner, D. E. ;
|
| CORP Author |
IIT Research Inst., Chicago, IL.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
| Year Published |
1981 |
| Report Number |
EPA-68-02-1273; EPA-600/J-81-603; |
| Stock Number |
PB83-140822 |
| Additional Subjects |
Air pollution ;
Bacterial diseases ;
Aerosols ;
Nitrogen organic compounds ;
Susceptibility(Physiology) ;
Mice ;
Laboratory animals ;
Reprints ;
Peroxyacetyl nitrate ;
Streptococcus pyogenes ;
Photochemical oxidants
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-140822 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
18p |
| Abstract |
A significant increase in mortality due to acute respiratory pneumonia caused by inhalation of Streptococcus pyogenes aerosol was seen after a single 3-h exposure of mice to 14.8-28.4 mg/cu.m. peroxyacetyl nitrate (PAN). The excess mortality ranged from 8 to 39% and the decrease in survival time from 2.4 to 7.9 d. A single exposure to 25.0 mg/cu.m. PAN resulted in a significant increase in total number of cells lavaged from the lungs but somewhat decreased levels of ATP in alveolar macrophages. PAN did not produce any marked changes in a chronic respiratory infection in mice as measured by Mycobacterium tuberculosis lung titers. |
