| Main Title |
Initial Submission: Chronic Mouse Dermal Toxicity Study of a Mixture of Valeric Acid; Heptanoic Acid; Pelargonic Acid; and Tripropylene Glycol of Hexafluoroisopropanol in Guinea Pigs and Rats with Cover Letter dated 10/15/1992. |
| CORP Author |
Charles F. Kettering Research Lab., Yellow Springs, OH.; Rhone-Poulenc Ag Co., Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-1092-11669 |
| Stock Number |
OTS0571597 |
| Additional Subjects |
Toxicology ;
Health effects ;
Valeric acid ;
Heptanoic acid ;
Pelargonic acid ;
Tripropylene ;
Chronic toxicity ;
Carcinogenicity ;
Mammals ;
Mice ;
Dermal ;
CAS No 109-52-4 ;
CAS No 111-14-8 ;
CAS No 112-05-0 ;
CAS No 42978-66-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0571597 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
105p |
| Abstract |
Groups of 50 male mice received twice-weekly applications of 25 or 50 mg doses of a test material. C-181 induced four skin tumors in three mice when tested in 50 mg doses as a 75% solution in mineral oil. Both benign and malignant skin tumors were observed in 1750 mice treated with C-180 along with severe dermal and systemic toxicity. An 18% decrease in average body weight and a marked reduction in survival was observed with C-180. No skin tumors were observed with either C- 178 or C-182. |
